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exogenous antioxidants come from outside the body

In addition to direct screening, engineering wild-type NAMPT is considered essential for increasing its enzymatic activity ( Huang et al., 2022 )

It has been shown that, during chemotherapy, tumor cells could overcome drug-induced OS by enhancing their antioxidant systems as well as an increasing P-gp pump efflux to acquire a new redox balance due the increased ROS accumulation and antioxidant systems in a process of redox rearranging (see Figure 1)

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Moreover, research has shown that sleep deprivation can reduce testosterone levels and that the recovery of testosterone levels is impaired in old rats compared with young rats [72]